- 3SITES - Catheter-Related Infections and Thrombosis in ICU Patients
A
- A-HeFT - Iso-Dinitrate Plus Hydralazine in Black Patients with Heart Failure
- ACCOMPLISH - Benazepril-Amlodipine or Benazepril-Hydrochlorothiazide in High-Risk Patients with Hypertension
- ACCORD Lipid - Fenofibrate and Simvastatin Not Beneficial in Reducing Cardiovascular Events in Patients with Type 2 Diabetes
- ACT I - Carotid-Artery Stenting versus Endarterectomy in Asymptomatic Patients
- ACTIVE A - Clopidogrel with Aspirin in High-Risk Patients with Atrial Fibrillation (ACTIVE A)
- ACTT-1 - Remdesivir for the Treatment of Covid-9 — Final Report
- ACURASYS - Cisatracurium in Early Acute Respiratory Distress Syndrome
- ADRENAL - Hydrocortisone for Patients with Septic Shock on Mechanical Ventilation
- ADVOR - Acetazolamide in Patients with Acute Decompensated Heart Failure with Volume Overload
- AF-CHF - Atrial Fibrillation and Congestive Heart Failure Treatment Strategies
- AFFIRM - Management Strategies for Atrial Fibrillation
- AID-ICU - Haloperidol for Delirium in Intensive Care Unit Patients
- AIDA - Bioresorbable Vascular Scaffolds versus Metallic Stents in Routine PCI
- AKIKI - Timing of Renal Replacement Therapy in Acute Kidney Injury
- ALBIOS - Albumin Replacement in Patients with Severe Sepsis or Septic Shock
- AMPLIFY - Apixaban versus Conventional Therapy in Venous Thromboembolism
- AMPLIFY-EXT - Extended Anticoagulation with Apixaban for Venous Thromboembolism
- ANNEXA - Reversal of Anticoagulation
- ANNEXA-4 - Andexanet Alfa for Reversing Anticoagulation from Factor Xa Inhibitors
- ANRS IPERGAY - Antiretroviral Preexposure Prophylaxis for HIV Prevention in Men Who Have Sex with Men
- ANTLER - Effect of Antidepressant Discontinuation vs. Maintenance on Relapse in Primary Care Patients
- APEX - BRIXABAN for Acute Medical Illness
- APROCCHSS - Corticosteroids in Septic Shock: The APROCCHSS Trial
- ARDSNet - Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
- ARISE - Early Goal-Directed Therapy in the Treatment of Septic Shock
- ARISTOTLE - Apixaban versus Warfarin in Patients with Atrial Fibrillation
- ART - Outcomes after Bilateral vs. Single Internal Thoracic Artery Grafting in Coronary-Artery Bypass Surgery
- ASCEND (Aspirin) - Aspirin for Primary Prevention in Diabetes Mellitus
- ASCEND (IPF) - Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
- ASPIRE - Aspirin for the Prevention of Recurrent Venous Thromboembolism
- ASPREE - Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer in the Elderly
- ASTRAL - Revascularization versus Medical Therapy for Renal-Artery Stenosis
- ATHOS-3 - Angiotensin II for the Treatment of Vasodilatory Shock
- ATN - Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
- ATTR-ACT - Tafamidis in Transthyretin Amyloid Cardiomyopathy
- ATTRACT - Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis
- AUGUSTUS - Antithrombotic Therapy in Patients with Atrial Fibrillation following Acute Coronary Syndrome or PCI
- AURORA - Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis
- AVERROES - Apixaban versus Aspirin in Patients with Atrial Fibrillation
- AVERT - Apixaban for Thromboprophylaxis in Cancer Patients
- AZT Trial - Azidothymidine (AZT) in Patients with AIDS or Advanced AIDS-Related Complex
- Albumin for SBP - Albumin Infusion in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis
B
- BARI 2D - Intensive Medical Therapy for Type 2 Diabetes and Stable Ischemic Heart Disease
- BEST - Comparison of Everolimus-Eluting Stents or Bypass Surgery for Multivessel Disease (BEST Trial)
- BLOCK-HF - Biventricular Pacing in Patients with Atrioventricular Block and Heart Failure
- BRIDGE - Bridging Anticoagulation in Patients with Atrial Fibrillation
- BRIM-3 - Vemurafenib versus Dacarbazine for Metastatic Melanoma with BRAF V600E Mutation
- Benazepril in Severe CKD - Benazepril in Patients with Advanced Chronic Renal Insufficiency
- Blood Pressure Reduction in Black Barbershops - Barbershop Interventions for Blood Pressure Reduction in Black Men
C
- CANTOS - Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS)
- CANVAS - Canagliflozin in Patients with Type 2 Diabetes and Cardiovascular Disease
- CAP-START - Empirical Antibiotic Treatment Strategies for Community-Acquired Pneumonia
- CAPE COD - Hydrocortisone in Severe Community-Acquired Pneumonia
- CARAVAGGIO - Apixaban for the Treatment of Venous Thromboembolism in Patients with Cancer
- CARP - Coronary-Artery Revascularization before Elective Major Vascular Surgery (CARP Trial)
- CARRESS-HF - Comparison of Ultrafiltration and Pharmacologic Therapy in Acute Decompensated Heart Failure
- CASSINI - Thromboprophylaxis with Rivaroxaban in High-Risk Ambulatory Patients with Cancer
- CASTLE-AF - Catheter Ablation for Atrial Fibrillation with Heart Failure
- CATIE - Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
- CATIE-AD - Atypical Antipsychotic Drugs in Alzheimers Disease
- CATT - Bevacizumab and Ranibizumab for Neovascular Age-Related Macular Degeneration (AMD)
- CHAMPION PHOENIX - Cangrelor During PCI
- CHANCE - Clopidogrel with Aspirin in High-Risk Patients with Acute Non-Disabling Cerebrovascular Events (CHANCE)
- CHARISMA - Clopidogrel plus Aspirin versus Aspirin Alone in High-Risk Patients
- CHOICE - Contraceptive CHOICE Project and Its Impact on Teen Pregnancy
- CHOIR - Hemoglobin Target in Chronic Kidney Disease
- CIRT - Inflammation and risk of atherothrombosis: Methotrexate versus placebo
- CLOSURE I - Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale
- CLOT - Dalteparin versus Oral Anticoagulant Therapy for the Prevention of Recurrence in Patients with Cancer and Venous Thromboembolism
- COAPT - Transcatheter Mitral-Valve Repair in Heart Failure Patients with Mitral Regurgitation
- COGENT - Clopidogrel with or without Omeprazole in Coronary Artery Disease
- COLCOT - Colchicine in Patients with Recent Myocardial Infarction
- COLONPREV - Comparative Effectiveness of Colonoscopy vs Fecal Immunochemical Testing for Colorectal Cancer Screening
- COMPASS - Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
- CONSENSUS - Enalapril in Severe Congestive Heart Failure
- CORAL - Renal-Artery Stenting versus Medical Therapy for Atherosclerotic Renal-Artery Stenosis
- CORONA - Rosuvastatin in Older Patients with Systolic Heart Failure
- CORTICUS - Corticosteroid Therapy of Septic Shock (CORTICUS)
- COURAGE - Percutaneous Coronary Intervention for Stable Coronary Artery Disease
- CRB-401 - CAR T-Cell Therapy bb22 in Relapsed or Refractory Multiple Myeloma
- CREST - Carotid Stenting vs. Endarterectomy Trial (CREST)
- CULPRIT-SHOCK - Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK)
- CURE - Clopidogrel in Patients with Acute Coronary Syndromes
- CYTO-PV - Hematocrit Targeting in Polycythemia Vera
- CheckMate-003 - Programmed Death Blockade in Cancer Treatment
- Compare-Acute - FFR-Guided PCI in ST-Segment Elevation Myocardial Infarction
- Cytisine for Smoking Cessation - Cytisine versus Nicotine-Replacement Therapy for Smoking Cessation
D
- DANISH - ICD in Patients with Nonischemic Systolic Heart Failure and the Risk of Sudden Cardiac Death
- DAPA-CKD - Dapagliflozin in Patients with Chronic Kidney Disease
- DAPA-HF - Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
- DAPT - Dual Antiplatelet Therapy with Clopidogrel and Aspirin in Coronary Stenting
- DASH - Dietary Approaches to Stop Hypertension (DASH) Study
- DAWN - Thrombectomy 6 to 24 Hours after Stroke
- DEFINITE - Mortality and Morbidity with an Implantable Cardioverter–Defibrillator in Patients with Nonischemic Dilated Cardiomyopathy
- DELIVER - Dapagliflozin in Heart Failure with Preserved Ejection Fraction (DELIVER)
- DETO2X-AMI - Routine Oxygen Therapy in Suspected Acute Myocardial Infarction
- DIG - Mortality and Hospitalization in Heart Failure Patients on Digoxin
- DINAMIT - Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
- DONATE-HCV - Transplantation Outcomes in Organ Recipients from Donors with HCV Viremia
- DOSE - Diuretic Strategies in Patients with Acute Decompensated Heart Failure
- Daily ICU Sedation Holidays - Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation
- Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile - Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection
E
- EARLY-AF - Catheter Ablation vs. Antiarrhythmic Drug Therapy for Atrial Fibrillation
- EASE - Early Surgery versus Conventional Treatment for Infective Endocarditis
- EAST-AFNET 4 - Early Rhythm-Control Therapy in Patients with Atrial Fibrillation
- ECASS III - Alteplase for Stroke 3 to 4.5 Hours after Onset
- EINSTEIN CHOICE - Rivaroxaban for the Prevention of Venous Thromboembolism
- EINSTEIN-PE - Rivaroxaban versus Standard Therapy for Pulmonary Embolism Treatment
- ELITE-Symphony - Daclizumab, Mycophenolate Mofetil, and Corticosteroids Combined with Low-Dose Tacrolimus, Cyclosporine, or Sirolimus in Renal Transplantation
- EMBRACE - Atrial fibrillation detection after stroke
- EMILIA - Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
- EMPA-REG OUTCOME - Empagliflozin in High Cardiovascular Risk Patients with Type 2 Diabetes
- EMPHASIS-HF - Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms
- ENGAGE AF-TIMI 48 - Edoxaban versus Warfarin in Patients with Atrial Fibrillation
- EPCAT II - Extended Thromboprophylaxis with Aspirin versus Rivaroxaban after Total Hip or Knee Arthroplasty
- EPHESUS - Eplerenone in Patients with Left Ventricular Dysfunction after Myocardial Infarction
- ERSPC - European Randomized Study of Screening for Prostate Cancer (ERSPC)
- ESSENCE - Enoxaparin versus Unfractionated Heparin in Unstable Coronary Artery Disease
- EUCLID (Ticagrelor) - Ticagrelor versus Clopidogrel in Patients with Symptomatic Peripheral Artery Disease
- EVOLVE - Cinacalcet in Patients Undergoing Hemodialysis
- EXCEL - Percutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting in Left Main Coronary Artery Disease
- Early Palliative Care - Palliative Care in Patients with Metastatic Non–Small-Cell Lung Cancer
- Early TIPS - Early Use of TIPS in Patients with Cirrhosis and Variceal Bleeding
- European Dexamethasone Study - Dexamethasone in Adults with Bacterial Meningitis
F
- FACTT - Fluid Management Strategies in Acute Lung Injury
- FAIR-HF - Iron Supplementation in Heart Failure with Reduced Ejection Fraction and Iron Deficiency
- FAME - Fractional Flow Reserve-Guided PCI versus Angiography for Multivessel Evaluation (FAME) Study
- FAME 2 - Fractional Flow Reserve-Guided PCI for Stable Coronary Artery Disease
- FEAST - Fluid Boluses in African Children with Severe Infection
- FIRE AND ICE - Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation
- FLAME (COPD) - Indacaterol–Glycopyrronium versus Salmeterol–Fluticasone for COPD
- FOCUS - Liberal or Restrictive Transfusion after Hip Fracture Surgery
- FOURIER - Evolocumab in Patients with Cardiovascular Disease
- FREEDOM - CABG vs. PCI in Diabetes with Multivessel Disease
- Fidaxomicin in C. difficile Diarrhea - Fidaxomicin versus Vancomycin for Clostridium difficile Infection
G
- GI bleeding in ICU patients - Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients
- GUSTO - Mortality and Morbidity with Thrombolytic Regimens in Myocardial Infarction: The GUSTO Trial
H
- HACA - Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest
- HEARTMATE II - Comparison of Continuous-Flow and Pulsatile-Flow Left Ventricular Assist Devices in Advanced Heart Failure
- HEAT - Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
- HEMO - Dialysis Dose and the Effect of Membrane Flux in Maintenance Hemodialysis
- HERA - Trastuzumab for HER2-Positive Early Breast Cancer
- HOPE (Sickle Cell Disease) - Voxelotor in Patients with Sickle Cell Disease (HOPE Trial)
- HOPE - Ramipril in High-Risk Patients
- HOPE-3 - Combined Effects of Lowering LDL Cholesterol and Blood Pressure on Cardiovascular Disease
- HORIZON-PFT - Zoledronic Acid and Fracture Risk Reduction
- HPS2-THRIVE - Extended-Release Niacin or Laropiprant and Vascular Outcomes
- HPTN 052 - Antiretroviral Therapy for the Prevention of HIV- Transmission
- HYPRESS - Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Respiratory Distress Syndrome
- HYVET - Hypertension Treatment in the Very Elderly
- Hokusai-VTE - Edoxaban versus Dalteparin for Cancer-Associated Venous Thromboembolism
- Hungarian Prenatal Vitamin Trial - Periconceptional Multivitamin and Folic Acid Supplementation Prevents Neural Tube Defects
I
- IABP-SHOCK II - Intraaortic Balloon Counterpulsation in Acute Myocardial Infarction-Complicated Cardiogenic Shock
- IALT - Cisplatin-Based Adjuvant Chemotherapy in Patients with Completely Resected Non-Small-Cell Lung Cancer
- ICAP - Colchicine for Acute Pericarditis (ICAP)
- IDEAL - Initiating Dialysis Early and Late (IDEAL) Study
- IDEAL-ICU - Renal-Replacement Therapy in Septic Shock with Acute Kidney Injury
- IFR-SWEDEHEART - Instantaneous Wave-Free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome
- IMPROVE-IT - Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
- INPULSIS Trials - Nintedanib for Idiopathic Pulmonary Fibrosis
- INSIGHT START - Immediate Antiretroviral Therapy in Early HIV Infection
- IPrEx - Preexposure Prophylaxis with FTC-TDF for HIV Prevention in Men
- IRIS - Imatinib versus Interferon Alfa plus Cytarabine in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
- ISAR-REACT 5 - Ticagrelor versus Prasugrel in Acute Coronary Syndromes
- ISCHEMIA - Invasive Strategy vs. Conservative Strategy in Stable Coronary Disease and Moderate or Severe Ischemia
- Ibrutinib in Waldenstrom macroglobulinemia - Ibrutinib for Previously Treated Waldenströms Macroglobulinemia
- Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia - Ibrutinib–Rituximab or Chemoimmunotherapy for CLL
J
- JUPITER - Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
K
- KEYNOTE-024 - Pembrolizumab versus Chemotherapy for PD-L–Positive Non–Small-Cell Lung Cancer
L
- LEADER - Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
- LESS - Epidural Glucocorticoids for Spinal Stenosis
- LenDex in High-Risk Smoldering Myeloma - Clinical Question
- Lo-Coco 2013 - ATRA plus Arsenic Trioxide for Acute Promyelocytic Leukemia
- LoDoCo2 - Colchicine in Patients with Chronic Coronary Disease
- Look AHEAD - Intensive Lifestyle Intervention in Type 2 Diabetes
M
- MADIT-CRT - Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events
- MADIT-II - Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
- MAGELLAN - Extended Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients
- MARINER - Extended Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients
- MASTER DAPT - Dual Antiplatelet Therapy Duration in High-Bleeding-Risk Patients After Stent Implantation
- MATRIX Antithrombin - Bivalirudin versus Heparin in Acute Coronary Syndrome
- METEOR - Arthroscopic Partial Meniscectomy versus Physical Therapy in Patients with Degenerative Meniscus Tears
- MIND-USA - Antipsychotic Medications for Delirium in the Intensive Care Unit
- MIST2 - Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection
- MODIFY I and II - Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection
- MOMENTUM 3 - Clinical Outcomes in Advanced Heart Failure Patients with Centrifugal-Flow vs. Axial-Flow Pump
- MOST - Dual-Chamber versus Ventricular Pacing in Sinus-Node Dysfunction
- MPACT - Nab-Paclitaxel plus Gemcitabine for Metastatic Pancreatic Cancer
- MR CLEAN - Intraarterial Treatment for Acute Ischemic Stroke in the MR CLEAN Trial
- MR RESCUE - Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
- MSH - Hydroxyurea for the Treatment of Sickle Cell Anemia
- MUSTT - Electrophysiologically Guided Antiarrhythmic Therapy in Coronary Artery Disease Patients
- Moseley Trial - A Randomized, Placebo-Controlled Trial of Arthroscopy for Osteoarthritis of the Knee
N
- NA-ACCORD - Timing of Antiretroviral Therapy for HIV- Infection and Mortality
- NASCET - Carotid Endarterectomy for Moderate Stenosis
- NAVIGATE ESUS - Rivaroxaban versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients with Recent Embolic Stroke of Undetermined Source (NAVIGATE ESUS)
- NCDS - Morbidity Effects of Hemodialysis Dose and Membrane Flux
- NEAT-HFpEF - Nitrates in Patients with Heart Failure and Preserved Ejection Fraction (NEAT-HFpEF Trial)
- NETT - Mortality and Morbidity in Patients with Severe Emphysema Treated with Lung-Volume-Reduction Surgery or Medical Therapy
- NLST - National Lung Screening Trial (NLST)
- NORSTENT - Long-term Outcomes with Drug-Eluting Stents versus Bare-Metal Stents in Norway
- NordICC - Clinical Effectiveness of Colonoscopy Screening in Reducing Colorectal Cancer Risk
- Novel START - As-needed Budesonide–Formoterol in Mild Asthma
O
- OASIS-5 - Fondaparinux versus Enoxaparin in Acute Coronary Syndromes (OASIS-5 Trial)
- OAT - Percutaneous Coronary Intervention in Stable Patients with Occluded Infarct-Related Artery
- ODYSSEY LONG TERM - Alirocumab for Hypercholesterolemia in Statin-Treated Patients
- ONTARGET - Comparing Angiotensin Receptor Blockers and ACE Inhibitors for Patients with Vascular Disease or High-Risk Diabetes
- ORIGIN n-3 Fatty Acids - N-3 Fatty Acids in High-Risk Patients with Dysglycemia
- OSCILLATE - High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome
- OVIVA - Oral versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA)
- Omeprazole in Peptic Ulcer Bleeding - High-Dose Proton-Pump Inhibitor for Peptic Ulcer Hemorrhage
P
- PANTER - Minimally Invasive Step-Up Approach Versus Open Necrosectomy in Necrotizing Pancreatitis
- PARADIGM-HF - LCZ696 versus Enalapril in Heart Failure
- PARAGON-HF - Sacubitril-Valsartan in Heart Failure with Preserved Ejection Fraction
- PARTNER 2 - Transcatheter versus Surgical Aortic-Valve Replacement in Intermediate-Risk Patients
- PARTNER 3 - TAVR versus Surgery for Aortic Stenosis in Patients at Low Surgical Risk
- PARTNER A - Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
- PARTNER B - Transcatheter Aortic-Valve Implantation for Inoperable Severe Aortic Stenosis
- PCPT - Finasteride in the Prevention of Prostate Cancer
- PEGASUS-TIMI 54 - Ticagrelor in Patients to 3 Years after Myocardial Infarction
- PEITHO - Tenecteplase in Normotensive Patients with Pulmonary Embolism
- PESIT - Pulmonary Embolism Prevalence in Patients Hospitalized for Syncope
- PIONEER AF-PCI - Rivaroxaban with or without Aspirin in Patients with Recent PCI and Atrial Fibrillation
- PIONEER-HF - Sacubitril–Valsartan vs. Enalapril in Acute Decompensated Heart Failure
- PIOPED II - Multidetector Computed Tomographic Angiography in Diagnosis of Pulmonary Embolism
- PLATO - Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
- POET - Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis
- POINT - Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA
- POISE-2 ASA - Aspirin in Patients Undergoing Noncardiac Surgery
- PRAETORIAN - Clinical Question
- PRAMI - Preventive Angioplasty in Acute Myocardial Infarction (PRAMI)
- PRECISION - Celecoxib vs. Ibuprofen or Naproxen in Patients with Increased Cardiovascular Risk
- PREDIMED - Mediterranean Diet for Primary Prevention of Cardiovascular Disease
- PREPIC - Efficacy of Vena Caval Filters in Preventing Pulmonary Embolism in Patients with Deep-Vein Thrombosis
- PREVENT TB - Rifapentine and Isoniazid for 3 Months versus Isoniazid for 9 Months
- PRODIGE 4 ACCORD 11 - FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
- PROLONG - Duration of Anticoagulation after Venous Thromboembolism
- PROSEVA - Prone Positioning in Severe Acute Respiratory Distress Syndrome
- PROVE IT-TIMI 22 - Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
- PROWESS - Drotrecogin Alfa (Activated) in Severe Sepsis
- PROWESS-SHOCK - Drotrecogin Alfa (Activated) in Adults with Septic Shock
- PRoFESS - Comparison of Aspirin plus Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke
- Prednisolone in Severe Alcoholic Hepatitis - Corticosteroids in the Treatment of Severe Alcoholic Hepatitis
- ProCESS - Protocol-Based Care for Early Septic Shock
- ProMISe - Protocolized Resuscitation in Early Septic Shock (ProMISe)
R
- RACE II - Lenient vs Strict Rate Control in Patients with Atrial Fibrillation
- RAFT - Cardiac-Resynchronization Therapy in Heart Failure with QRS Complex
- RALES - Spironolactone for Severe Heart Failure
- RAMPART - Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus
- RAVE - Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
- RE-ALIGN - Dabigatran versus Warfarin in Patients with Mechanical Heart Valves
- RE-COVER - Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism
- RE-DUAL - Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
- RE-LY - Dabigatran versus Warfarin in Patients with Atrial Fibrillation
- RE-VERSE AD - Idarucizumab for Dabigatran Reversal
- RECOVERY (Covid-19) - Dexamethasone in Hospitalized Patients with Covid-9
- RED-HF - Darbepoetin Alfa in Systolic Heart Failure and Anemia
- REDUCE-IT - Icosapent Ethyl for Elevated Triglyceride Levels
- REMATCH - Left Ventricular Assist Device as Destination Therapy in End-Stage Heart Failure
- RESCUEicp - Decompressive Craniectomy in Diffuse Traumatic Brain Injury
- RESPECT - PFO Closure vs. Medical Therapy in Stroke Prevention
- RITUXVAS - Rituximab versus Cyclophosphamide in ANCA-Associated Vasculitis
- ROCKET AF - Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
- ROSE - Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome
- Rivers Trial - Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
S
- SAFE - Saline versus Albumin Fluid Evaluation (SAFE) in ICU Patients
- SALT-ED - Balanced Crystalloids versus Saline in Noncritically Ill Adults
- SAMMPRIS - Stenting vs. Aggressive Medical Therapy for Intracranial Arterial Stenosis
- SAVE - Captopril in Patients with Left Ventricular Dysfunction After Myocardial Infarction
- SCD-HeFT - Implantable Cardioverter-Defibrillator in Patients with Congestive Heart Failure
- SEPSISPAM - Mean Arterial Pressure Targets in Septic Shock
- SHOCK - Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock
- SMART-MED and SMART-SURG - Balanced Crystalloids versus Saline in Critically Ill Adults
- SOAP II - Dopamine and Norepinephrine in Shock
- SOCRATES - Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack
- SOLVD - Enalapril for Chronic Heart Failure with Reduced Ejection Fraction
- SOME - Screening for Occult Cancer in Unprovoked Venous Thromboembolism
- SONIC - Infliximab, Azathioprine, or Combination for Crohns Disease
- SPARCL - Atorvastatin for Stroke Prevention
- SPICE III - Dexmedetomidine for Sedation in Mechanically Ventilated ICU Patients (SPICE III)
- SPRINT - Systolic Blood Pressure Intervention Trial (SPRINT)
- SPS3 Clopidogrel-ASA - Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack
- STEP - Systolic Blood Pressure Intervention in Elderly Hypertensive Patients
- STEP 1 - Semaglutide in Adults with Overweight or Obesity
- STICH - CABG in Patients with Heart Failure and Coronary Artery Disease
- STOP-IT - Antibiotic Therapy for Intraabdominal Infection after Adequate Source Control
- STOPAH - Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH) Trial
- SURTAVI - TAVR versus Surgery in Patients with Intermediate-Risk Aortic Stenosis
- SUSTAIN - Crizanlizumab in Sickle Cell Disease
- SWOG 8949 - Nephrectomy Plus Interferon Alfa-2b versus Interferon Alfa-2b Alone in Metastatic Renal-Cell Cancer
- SYNTAX - Comparative Efficacy of PCI with Drug-Eluting Stents vs. CABG in Three-Vessel or Left Main Coronary Artery Disease
T
- TACTICS-TIMI 18 - Early Invasive vs. Conservative Strategy in Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction
- TALC - Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy
- TIMACS - Early Versus Delayed Intervention in Acute Coronary Syndromes
- TNT - Mortality and Morbidity in Patients with Stable Coronary Heart Disease and LDL Cholesterol Levels
- TOPCAT - Spironolactone for Heart Failure with Preserved Ejection Fraction (TOPCAT Study)
- TOPPS - Prophylactic Platelet Transfusions in Hematologic Cancers
- TORCH - Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease
- TRICC - Restrictive versus Liberal Transfusion Strategy in Critically Ill Patients
- TRICS III - Restrictive Red-Cell Transfusion Strategy in Cardiac Surgery
- TRISS - Transfusion Requirements in Septic Shock (TRISS) Trial
- TRITON-TIMI 38 - Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes
- TRIUMPH - Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria
- TTM - Targeted Temperature Management at 33°C Versus 36°C after Cardiac Arrest
- TTM2 - Hypothermia vs. Normothermia after Out-of-Hospital Cardiac Arrest
- Transfusion Strategies for Acute Upper Gastrointestinal Bleeding - Restrictive versus Liberal Transfusion Strategy in Patients with Acute Upper Gastrointestinal Bleeding
- Twice-daily RT for SCLC - Twice-Daily versus Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated with Cisplatin and Etoposide
U
- UPLIFT - Tiotropium and Outcomes in Chronic Obstructive Pulmonary Disease
V
- V-HeFT - Vasodilator Therapy for Chronic Congestive Heart Failure
- V-HeFT II - Enalapril vs. Hydralazine-Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure
- VA Cooperative Study - Aspirin in Unstable Angina Trial
- VA-NEPHRON D - Combination Therapy in Patients with Diabetic Nephropathy
- VADT - Intensive Glucose Control in Type 2 Diabetes
- VALENCE - Sofosbuvir–Ribavirin for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
- VALIANT - Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both
- VANISH - Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs
- VASST - Vasopressin vs Norepinephrine in Septic Shock
- VEST - Wearable Cardioverter-Defibrillator after Myocardial Infarction
- VITAL (Vitamin D arm) - Vitamin D, Omega-3 Trial (VITAL)
- VOYAGER-PAD - Rivaroxaban in Peripheral Artery Disease after Revascularization (VOYAGER PAD Trial)
- Val-HeFT - Valsartan in Heart Failure Patients Already Treated with ACE Inhibitors
- Veterans Affairs Status Epilepticus Cooperative Study Group - Treatment of Generalized Convulsive Status Epilepticus
W
- WARFASA - Aspirin for the Secondary Prevention of Venous Thromboembolism
- WARSS - Warfarin vs. Aspirin in Patients with Recurrent Ischemic Stroke
- WASID - Warfarin versus Aspirin for Symptomatic Intracranial Disease (WASID) Trial
- WISDOM - Inhaled Glucocorticoids in Triple Therapy for Severe COPD
- WOSCOPS - Pravastatin in the Primary Prevention of Coronary Events
Y
- Yang-Tobin Study - Weaning from Mechanical Ventilation: Predictive Indices